Vampire Killer could refer to:
- 1986 — Vampire Killer, the famous theme first introduced in the game Castlevania.
- 1986 — Vampire Killer, the 1986 MSX2 game.
- 1994 — Vampire Killer, the Japanese name for the Sega Mega Drive game Castlevania: Bloodlines.
- 1994 — Vampire Killer, the mysterious whip owned by the Belmont Clan. Its name is first introduced in Castlevania: Bloodlines.
- 2010 — Vampire Killer, the original Combat Cross, used by Gabriel Belmont in Castlevania: Lords of Shadow.
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